Mitochondrial protein import machineries and lipids: A functional connection
نویسندگان
چکیده
منابع مشابه
Mitochondrial protein import machineries and lipids: a functional connection.
Protein trafficking and translocation are essential processes in even the simplest living cells. The compartmentalisation within eukaryotic cells places a very high demand on the fidelity of protein trafficking and translocation, since a large percentage of the cell's protein complement is inserted into, or translocated across membranes. Indeed, most mitochondrial proteins are imported from the...
متن کاملMitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries.
Mitochondrial protein import (MPI) is essential for the biogenesis of mitochondria in all eukaryotes. Current models of MPI are predominantly based on experiments with one group of eukaryotes, the opisthokonts. Although fascinating genome database-driven hypotheses on the evolution of the MPI machineries have been published, previous experimental research on non-opisthokonts usually focused on ...
متن کاملMitochondrial protein import.
Most mitochondrial proteins are synthesized as precursor proteins on cytosolic polysomes and are subsequently imported into mitochondria. Many precursors carry amino-terminal presequences which contain information for their targeting to mitochondria. In several cases, targeting and sorting information is also contained in non-amino-terminal portions of the precursor protein. Nucleoside triphosp...
متن کاملThe mitochondrial protein import apparatus.
INTRODUCTION ..................................................................................... 331 THE PRECURSOR PROTEINS .................................................................... 332 Targeting Signals ................................................................................. 332 Translocation Competence ........................................................................
متن کاملMechanisms of mitochondrial protein import.
Mitochondria import most of their proteins from the cytosol. Precursor forms of most matrix proteins as well as some IM and IMS proteins are synthesized on cytoplasmic ribosomes with N-terminal cleavable signal sequences. Many other mitochondrial proteins including IM carrier proteins contain internal targeting sequences. Three multisubunit translocases, one in the OM and two in the IM, partici...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2011
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2010.08.003